Association of Low Serum Ferritin Levels in Patients Having Alopecia Areata: A Case Control Study
DOI:
https://doi.org/10.47489/szmc.v38i2.425Keywords:
Alopecia Areata, Serum ferritin levels, Iron deficiencyAbstract
Introduction: Alopecia areata is a medical condition characterized by non-scarring hair loss occurring in patches. Etiopatho-genesis of the disease involves genetic, immunological and various other factors. Reduced ferritin stores lead to impaired DNA synthesis disrupting hair follicle production hence playing a role in the patho-physiology of alopecia areata.
Aims & Objectives: To establish the association of low serum ferritin levels and alopecia areata.
Place and Duration of Study: The study was conducted for duration of six months from February to August 2022 at Dermatology Department Shalamar Hospital, Lahore.
Material & Method: A total of 104 participants were recruited for this study, into a group of 52 patients having alopecia areata and 52 age and gender matched healthy controls. All these participants were advised to get their serum ferritin levels done from the same laboratory to control bias. Values of serum ferritin levels were recorded in ng/ml on a predesigned proforma. The data was analyzed using SPSS version 23.0. Frequencies and percentages were calculated for qualitative variables, p ? 0.05 was considered statistically significant.
Results: Mean age was 30.63±4.15 years in case group and 29.94±3.65 years in control group. Within each group (n=52), 16 were males whereas 36 were females (p=1.000). Serum ferritin levels were 18.82±4.47ng/ml in case group and 20.92±4.31ng/ml in control group (p=0.017). Frequency of low serum ferritin level was 63%(29) in case group and 37 %(17) in control group (p=0.029) with significant Odds Ratio of 2.596.
Conclusion: We concluded that there is significant association of alopecia areata and low serum ferritin levels and early detection and restoration of iron stores may potentially enhance the management of alopecia areata.
References
Pratt CH, King LE, Messenger AG, Christiano AM, Sundberg JP. Alopecia areata (Primer). Nat Rev Dis Primers. 2017;3(1):17011.
Darwin E, Hirt PA, Fertig R, Doliner B, Delcanto G, Jimenez JJ. Alopecia areata: review of epidemiology, clinical features, pathogenesis, and new treatment options. Int J Trichology. 2018;10(2):51-60.
Mesinkovska N, King B, Mirmirani P, Ko J, Cassella
J. Burden of illness in alopecia areata: A cross- sectional online survey study. J InvDermSym Proceed. 2020;20(1):62-8
Mostaghimi A, Gao W, Ray M, Bartolome L, Wang T, Carley C, et al. Trends in Prevalence and Incidence of Alopecia Areata, Alopecia Totalis, and Alopecia Universalis Among Adults and Children in a US Employer-Sponsored Insured Population. JAMA Dermatol. 2023;159(4):411-18
Rajabi F, Drake LA, Senna MM, Rezaei N. Alopecia areata: a review of disease pathogenesis. Br J Dermatol. 2018;179(5):1033-48.
Devaraj Y, Devi B, Bachaspatimayum R. Correlation between serum ferritin and severity of alopecia areata. IndClinExpDermatol. 2019;5(4):336–9.
Redler S, Messenger AG, Betz RC. Genetics and other factors in the aetiology of female pattern hair loss. ExpDermatol. 2017;26(6):510-7.
Zhou C, Li X, Wang C, Zhang J. Alopecia areata: an update on etiopathogenesis, diagnosis, and management. Clinical Reviews in Allergy &Immunology. 2021;61(3):403-23.
Gangaiah N, Thimmappa V, Potlapati A, Gowda C. A case control study of relationship between body
iron stores and non-scarring diffuse hair loss in non- menopausal women. Indian J ClinExpDermatol. 2019;5(1):80-4.
Meah N, Wall D, York K, Bhoyrul B, Bokhari L, Sigall DA, Bergfeld WF, Betz RC, Blume-Peytavi U, Callender V, Chitreddy V. The Alopecia Areata Consensus of Experts (ACE) study: results of an international expert opinion on treatments for alopecia areata.JAAD.2020;83(1):123-30.
Chisti MA, Masood Q, Shah IH, Khan D, Majid I, Qayoom S, et al. Serum ferritin levels in non- scarring alopecia of women: a case-control study. JPAD. 2012;22(1):4–11.
Esfandiarpour I, Farajzadeh S, Abbaszadeh M. Evaluation of serum iron and ferritin levels in alopecia areata. Dermatol Online Journal. 2008;14(3):21.
Olsen EA, Reed KB, Cacchio PB, Caudill L. Iron deficiency in female pattern hair loss, chronic telogen effluvium and control groups. JAAD. 2010;63(6):991-9.
Abdaljawad S, Qiteesh H, Abdelgader A, Saed W. Serum Ferritin Level and Alopecia Areata in Pediatric Patients. Alq J Med App Sci. 2022;5(2):527–33.
Öner Ü, Akdeni?z N. Nonscarring scalp alopecia: Which laboratory analysis should we perform on whom? Turk J Med Sci. 2021;52(1):188-94
Aejaz AW, Nighat J. Serum iron and ferritin levels in alopecia areata. Iran JDermatol. 2011;14(3):92–4.
Treister-Goltzman Y, Yarza S, Peleg R. Iron Deficiency and Nonscarring Alopecia in Women: Systematic Review and Meta-Analysis. Skin App Dis. 2020;8(2):83–92.
Goksin S. Retrospective evaluation of Clinical Profileand Comorbidities in Patients with Alopecia Areata. North ClinIstanb. 2022;9(5):451-8.
Brittenham GM. Disorders of iron metabolism: iron deficiency and overload. In: Hoffman R, Benz EJ Jr, Shattil SJ, Furie B, Cohen HJ, Silberstein LE, McGlave P, editors. Hematology: basic principles and practice. 3rd ed. New York: Churchill- Livingstone; 2000:397–428.
Aslam MF, Khalid M, Aslam MA. The Association of Serum Ferritin Levels withNon-scarring Alopecia in Women.Cureus. 2022;14(12)e32123.
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