Serum Ferritin Level Linked to Male Type-2 Diabetes Mellitus Patients Amongst Residents of Hyderabad, Sindh

Authors

  • Syed Farhan Uddin Department of Physiology, Muhammad Medical College, Mirpurkhas, Pakistan.
  • Kiran Waheed Department of Biochemistry, Indus Medical College Tando Muhammad khan Pakistan.
  • Salma Sheikh Department of Physiology, Indus Medical College Tando Muhammad khan Pakistan.
  • Naila Noor Department of Physiology, Muhammad Medical College, Mirpurkhas, Pakistan.
  • Habib-ur-Rehman Chohan Department of Physiology, Muhammad Medical College, Mirpurkhas, Pakistan.
  • Syeda Mahnoor Department at Emergency Medicine LUMHS Jamshoro, Pakistan.
  • Syed Zain-ul-Abdeen Student at Bilawal Medical College LUMHS Jamshoro, Pakistan.

DOI:

https://doi.org/10.47489/szmc.v38i2.504

Keywords:

Diabetes Mellitus, Serum ferritin level, Association between two factors

Abstract

Introduction: Diabetes mellitus is a metabolic disorder which is caused by either deficiency of insulin or its disturbed action on peripheral receptors. Globally it is estimated that 451 million peoples were suffering from Diabetes mellitus type 2 in 2017 and this burden will rise to 693million in 2045.The relationship between diabetes mellitus and serum ferritin levels is intricately linked, sharing a common intersection in the liver where both glucose metabolism and iron metabolism converge.

Aims and Objectives: To measure the serum ferritin levels among residents of Hyderabad with type 2 Diabetes Mellitus.

Place and Duration of study: The study was conducted in the Outpatient Department (OPD) of Liaquat university Hospital from June 2022 to August 2022 (3 months).

Material and Methods: The study consists of 100 subjects divided into two groups, a control group consists of 50 normal healthy people with normal fasting glucose below 100mg/dl and a Case group consists of 50 patients with fasting glucose level more than 125 mg/dl according to World Health Organization criteria. Their Serum ferritin levels were evaluated using the ELFA method, employing a commercially available kit supplied by Roche Cobas Integra. The results were analyzed on the software Graph Pad Prism 9, p-value ? 0.05was taken as significant.

Results: The frequency of Type 2 Diabetes mellitus was significantly higher in patients with increased serum ferritin levels (P=0.001) with an odds ratio of 1.838 , a sensitivity/specifity value of (0.50/0.56) and a robust likelihood ratio of 2.25.

Conclusion: The study underscores a potential link between elevated serum ferritin and Diabetes Mellitus Type-2.

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Published

2024-04-29

How to Cite

1.
Syed Farhan Uddin, Kiran Waheed, Salma Sheikh, Naila Noor, Habib-ur-Rehman Chohan, Syeda Mahnoor, Syed Zain-ul-Abdeen. Serum Ferritin Level Linked to Male Type-2 Diabetes Mellitus Patients Amongst Residents of Hyderabad, Sindh. Proceedings S.Z.M.C [Internet]. 2024 Apr. 29 [cited 2024 Jun. 25];38(2):106-10. Available from: http://www.proceedings-szmc.org.pk/index.php/szmc/article/view/504